Performance of [68Ga]Ga-FAPI PET in Breast, Ovarian, and Cervical Cancers: A Systematic Review and Meta-Analysis

Gabdullina, Madina; Ainakulova, Akmaral; Elboga, Umut; Karibayeva, Indira; Alisherov, Galymzhan; Zhakenova, Zhanar; Amankulov, Jandos; Zholdybay, Zhamilya

doi:10.31557/APJCP.2026.27.4.1161

Performance of [68Ga]Ga-FAPI PET in Breast, Ovarian, and Cervical Cancers: A Systematic Review and Meta-Analysis

Document Type : Systematic Review and Meta-analysis

Authors

¹ Department of Visual Diagnostics, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.

² Faculty of Medicine and Healthcare, Al-Farabi Kazakh National University, Almaty, Kazakhstan.

³ Department of Oncology and Radiology, Kazakh Institute of Oncology and Radiology, Almaty, Kazakhstan.

⁴ Department of Nuclear Medicine, Faculty of Medicine, Gaziantep University, Gaziantep, Turkiye.

⁵ Department of Health Policy and Community Health, Jiann-Ping Hsu College of Public Health, Georgia Southern University, Statesboro, GA, USA.

10.31557/APJCP.2026.27.4.1161

Abstract

Objective: This meta-analysis aims to evaluate the diagnostic efficacy of [68Ga]Ga-FAPI PET imaging in breast, ovarian, and cervical cancers by conducting a systematic review of the existing literature. Methods: A systematic review of PubMed, Web of Science, Scopus, and Google Scholar databases, following by a meta-analysis of the included studies, was performed using a random-effects statistical model. Result: Ten eligible studies that described the effectiveness of [⁶⁸Ga]Ga-FAPI PET imaging in breast, ovarian, and cervical cancers were included in this review. The total number of participants was 253 females. Aggregated data from nine studies indicate a remarkably high diagnostic odds ratio (DOR) of 48.69 (95% CI: [16.94–139.96]) for detecting primary tumors, and a DOR of 207.50 (95% CI: [46.18–932.34]) from seven studies for detecting lymph node metastasis. [⁶⁸Ga]Ga-FAPI PET demonstrated high diagnostic accuracy in identifying both primary lesions and metastatic lymph nodes in breast, ovarian, and cervical cancers. Conclusion: [68Ga]Ga-FAPI PET imaging could function as a supplementary technique to [18F]F-FDG PET imaging modalities, offering a more comprehensive evaluation for cancer staging, assessment of treatment response, and guidance in radiation therapy planning.

Keywords