Objectives: To compare the qualitative and quantitative differences in several cell types between conventional cytology and liquid-based cytology samples in patients diagnosed with high-grade cervical intraepithelial neoplasia. Methods: A prospective, observational, cross-sectional study was conducted with 84 female patients at Santa Casa de Misericórdia de São Paulo Hospital (São Paulo, Brazil) between May 2019 and November 2020. Patients who underwent colposcopy-guided biopsy and were subsequently diagnosed with high-grade cervical intraepithelial neoplasia were included in this study. After the patients’ selection, relevant information, conventional cytology, and liquid-based cytology samples were collected in the same session. Results: Liquid-based cytology presented less neutrophilic infiltrate and a clean background, when compared to conventional cytology. We observed a larger amount of cell types (mature, basal, metaplastic, endocervical cells) in conventional cytology when compared to liquid-based cytology, with statistically significant results in all four cell types. We also observed a concordance rate of 90.6% in the cytological diagnosis between conventional and liquid-based cytologies. Conclusion: Even though we found a greater amount of cells in conventional cytology, the diagnostic accuracy of both cytologies is similar. Therefore, in places in where conventional cytology is employed as the main screening method, a proper diagnosis is achieved.
Curi, F. Salomão d’ Avila , Campaner, A. Bittencourt and De Sica, A. C. Alves Rosario (2026). Comparative Analysis of Quality of Cell Collected from the Cervix: Conventional versus Liquid-Based Cytology. Asian Pacific Journal of Cancer Prevention, 27(5), 1609-1614. doi: 10.31557/APJCP.2026.27.5.1609
MLA
Curi, F. Salomão d’ Avila, , Campaner, A. Bittencourt, and De Sica, A. C. Alves Rosario. "Comparative Analysis of Quality of Cell Collected from the Cervix: Conventional versus Liquid-Based Cytology", Asian Pacific Journal of Cancer Prevention, 27, 5, 2026, 1609-1614. doi: 10.31557/APJCP.2026.27.5.1609
HARVARD
Curi, F. Salomão d’ Avila, Campaner, A. Bittencourt, De Sica, A. C. Alves Rosario (2026). 'Comparative Analysis of Quality of Cell Collected from the Cervix: Conventional versus Liquid-Based Cytology', Asian Pacific Journal of Cancer Prevention, 27(5), pp. 1609-1614. doi: 10.31557/APJCP.2026.27.5.1609
CHICAGO
F. Salomão d’ Avila Curi , A. Bittencourt Campaner and A. C. Alves Rosario De Sica, "Comparative Analysis of Quality of Cell Collected from the Cervix: Conventional versus Liquid-Based Cytology," Asian Pacific Journal of Cancer Prevention, 27 5 (2026): 1609-1614, doi: 10.31557/APJCP.2026.27.5.1609
VANCOUVER
Curi, F. Salomão d’ Avila, Campaner, A. Bittencourt, De Sica, A. C. Alves Rosario Comparative Analysis of Quality of Cell Collected from the Cervix: Conventional versus Liquid-Based Cytology. Asian Pacific Journal of Cancer Prevention, 2026; 27(5): 1609-1614. doi: 10.31557/APJCP.2026.27.5.1609
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