Objective: The deregulation of the ubiquitin system is linked to several disorders, including cancer, and is implicated in MM. The study aimed to determine serum β-catenin and UCHL1 concentration and relate it to the risk of developing MM and to assess mitochondrial DNA by RT-qPCR. Methods: The study was conducted in October 2023 to February 2024. The study included 20 men and 20 women diagnosed with MM by their physicians and a total of 40 individuals who were in good health and had no prior medical history of MM . A 5 mL of blood were withdrawn from patients and controls groups. The serum beta-catenin protein (β-catenin) , ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) were measured by ELISA and mitochondrial DNA (mtDNA) was assessed by qPCR. Result: The results clearly showed a significant decrease in level of UCHL1, β-catenin in MM patients compared to level in control group ( P = 0.00018) . The result also showed elevated level of mtDNA synthesis in patients with MM compared to control group (P = 0.00014). Based on the research data, the patient group exhibited a significantly increase in levels of mtDNA synthesis compared to the control group (P = 0.01). Conclusion: Decreased serum β -catinine and UCHL1 levels, along with an increase in mtDNA synthesis seems to have significant role in the progress of MM.
Mahdi, W. and Jasib Almzaiel, A. (2026). Ubiquitin Protease Levels and Mitochondrial DNA Synthesis in Multiple Myeloma. Asian Pacific Journal of Cancer Prevention, 27(10), 3517-3523. doi: 10.31557/APJCP.2026.27.10.3517
MLA
Mahdi, W. , and Jasib Almzaiel, A. . "Ubiquitin Protease Levels and Mitochondrial DNA Synthesis in Multiple Myeloma", Asian Pacific Journal of Cancer Prevention, 27, 10, 2026, 3517-3523. doi: 10.31557/APJCP.2026.27.10.3517
HARVARD
Mahdi, W., Jasib Almzaiel, A. (2026). 'Ubiquitin Protease Levels and Mitochondrial DNA Synthesis in Multiple Myeloma', Asian Pacific Journal of Cancer Prevention, 27(10), pp. 3517-3523. doi: 10.31557/APJCP.2026.27.10.3517
CHICAGO
W. Mahdi and A. Jasib Almzaiel, "Ubiquitin Protease Levels and Mitochondrial DNA Synthesis in Multiple Myeloma," Asian Pacific Journal of Cancer Prevention, 27 10 (2026): 3517-3523, doi: 10.31557/APJCP.2026.27.10.3517
VANCOUVER
Mahdi, W., Jasib Almzaiel, A. Ubiquitin Protease Levels and Mitochondrial DNA Synthesis in Multiple Myeloma. Asian Pacific Journal of Cancer Prevention, 2026; 27(10): 3517-3523. doi: 10.31557/APJCP.2026.27.10.3517
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