Antiproliferative Effects of Curcumin Different Types of Breast Cancer

Document Type : Research Articles

Authors

Department of Biology, Faculty of Sciencei, Istanbul University, Istanbul, Turkey.

Abstract

Objective: Breast cancer is one of the most frequently diagnosed malignancy among women. Turmeric is isolated from Curcuma longa. Curcumin is main curcuminoid of the turmeric which is a member of Zingiberaceae. In this current study antiproliferative effects of curcumin were investigated in luminal A breast cancer cell line MCF-7 and triple negative breast cancer cell line MDA-MB-231. Methods: For this purpose cell viability, cell index values by xCELLigence Real-Time Cell Analysis DP instrument, mitotic index and apoptotic index analysis were used. Results: Cell viability and cell index values showed that 75 µM concentration of curcumin was IC50 concentration. When IC50 concentration was applied to both cell lines, a significant decrease was observed in the mitotic index values, while a significant increase was observed in the apoptotic index values (p<0.05). Conclusion: Curcumin, which has antiproliferative effects on breast cancer cells, is thought to be effective in cancer treatment.

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Asian Pacific Journal of Cancer Prevention
Volume 23, Issue 3
March 2022
Pages 911-917

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History

  • Receive Date: 24 September 2021
  • Revise Date: 15 February 2022
  • Accept Date: 23 March 2022

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