Multi-Target Cytotoxic Actions of Flavonoids in Blood Cancer Cells


To date, cytotoxic effects of flavonoids in various cancer cells are well accepted. However, the intracellularsignaling cascades triggered by these natural compounds remain largely unknown and elusive. In this minireview,the multiplicity of molecular targets of flavonoids in blood cancer cells is discussed by demonstrating theinvolvement of various signaling pathways in induction of apoptotic responses. Although these data reveal a greatpotential of flavonoids for the development of novel agents against different types of hematological malignancies,the pleiotropic nature of these compounds in modulation of cellular processes and their interactions certainlyneed unraveling and further investigation.