Background: Platelets are blood elements thought to play a role in the immune system and therefore tumordevelopment and metastasis. Platelet activation parameters such as mean platelet volume (MPV), plateletdistribution width (PDW), and plateletcrit (PCT) can be easily evaluated with the whole blood count and havebeen studied as markers of systemic inflammatory responses in various cancer types. Our aim in this study wasto evaluate the correlation between endometrial pathologies and MPV, PDW and PCT. Materials and Methods:A total of 194 patients who presented to our clinic with abnormal vaginal bleeding were included in our study.The patients were divided into 3 groups (endometrial hyperplasia, endometrial cancer, control) according to theirpathology results. The groups were compared for MPV, PDW, and PCT values obtained from the blood samplestaken on endometrial biopsy day. Results: The endometrial cancer patients were the oldest group (p=0.04).There was no significant difference between the three groups in terms of white blood cell count (WBC), plateletcount (PC), and hemoglobin (Hb) level. The highest MPV (p<0.001), PDW (p=0.002), and PCT (p<0.001) levelswere in the endometrial cancer group, and the lowest levels were in the control group. Conclusions: The easyevaluation of platelet parameters in patients who are suspected of having endometrial pathology is a significantadvantage. We found MPV, PDW, and PCT to be correlated with the severity of endometrial pathology with thehighest values in endometrial cancer. Studies to be conducted together with different laboratory parameters willfurther help evaluate the diagnosis and severity of endometrial cancer and precursor lesions.