Mean Platelet Volume as an Independent Predictive Marker for Pathologic Complete Response after Neoadjuvant Chemotherapy in Patients with Locally Advanced Breast Cancer

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Department of Medical Oncology, Antalya Research and Training Hospital, Antalya, Turkey

Abstract

Background: The impact of mean platelet volume (MPV) on prognosis, diagnosis and response to therapy in cancer patients has been widely investigated. In the present study, we evaluated whether MPV at diagnosis has predictive value for pathologic complete response (pCR) after neoadjuvant chemotherapy in patients with locally advanced breast cancer (LABC). Materials and Methods: A total of 109 patients with LABC from Akdeniz University and Antalya Research and Training Hospital were evaluated retrospectively. Results: ROC curve analysis suggested that the optimum MPV cut-off point for LABC patients with pCR () was 8.15 (AUC:0.378, 95%CI [0.256- 0.499], p=0.077). The patients with MPV
Asian Pacific Journal of Cancer Prevention
Volume 17, Issue 4 - Serial Number 4
April 2016
Pages 2089-2092

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