Vitamin D Deficiency Associated with Differentiated Thyroid Carcinoma: A Case- Control Study

Document Type : Research Articles


1 Department of Endocrinology and Metabolism, Zahedan University of Medical Sciences, Zahedan, Iran.

2 Department of Hematology and Oncology, Zahedan University of Medical Sciences, Zahedan, Iran.

3 Department of Pathology, Zahedan University of Medical Sciences, Zahedan, Iran.

4 Department of Endocrinology, AJA University of Medical Sciences, Tehran, Iran.

5 Department of Pediatric Nephrology, Zahedan University of Medical Sciences, Zahedan, Iran

6 Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.


Objective: In recent decades, the incidence of thyroid cancer has increased throughout the world. It is unclear whether factors such as vitamin D deficiency may have been involved in this increase. The present case-control study was conducted to examine any association between Vitamin D deficiency and thyroid cancers. Methods: The study was conducted on 85 patients with differentiated thyroid cancer diagnosed based on fine needle aspiration biopsy as the case group and 85 healthy controls. Serum levels of vitamin D were evaluated before thyroidectomy. For each patient in the case group, one healthy euthyroid person without any thyroid nodules from the general population matched based on season, sex, age (± 1 year) and BMI (± 1) was selected. Finally, 85 pairs were obtained considering inclusion and exclusion criteria. Thyroid function, thyroid antibodies and serum vitamin D were assessed and thyroid sonography was performed in all participants. Results: In the patient group, 72 (85%) were female and 13 (15%) were male. The mean (SD) serum vitamin D level was 8.00 (±3.7) in patient group, as compared to 13.4 (±7.90) in the control group, the difference being significant (OR: 6, 95 % CI: 1.02-113.3; P=0.046). Conclusion: A significant association was noted between vitamin D deficiency and differentiated thyroid cancer. Further studies with a prospective design are necessary to further define the roles of this factor.


Main Subjects

Volume 18, Issue 12
December 2017
Pages 3419-3422
  • Receive Date: 16 September 2017
  • Revise Date: 20 October 2017
  • Accept Date: 26 November 2017
  • First Publish Date: 01 December 2017