Background: We conducted this study to contribute to resolving some controversial issues on management of nasopharyngeal carcinoma. Methods: Thirty-two patients with stage III-IVB nasopharyngeal carcinoma were included in this retrospective study. All patients received concurrent chemoradiotherapy with either 3D conformal radiotherapy or intensity-modulated radiotherapy. We retrospectively analyzed the survival outcome, prognostic factors for survival, and toxicity outcome. Results: The 2- and 5-year overall survival rates were 89.9% and 82.6%. The 2- and 5-year distant metastasis-free survival rates were 83.2% and 79.4%. The 2- and 5-year loco-regional recurrence-free survival rates were 83.3% and 79.5%. Addition of induction chemotherapy to concurrent chemoradiotherapy did not improve survival outcomes. The survival benefit of intensity-modulated radiotherapy over 3D conformal radiotherapy was not clear. Intensity-modulated radiotherapy significantly decreased the development of late toxicities compared with 3D conformal radiotherapy. Total RT dose was prognostic factor for overall, loco-regional recurrence-free, and distant metastasis-free survival. Temporary RT interruption was prognostic factor for overall survival. Daily RT dose was prognostic factor for distant metastasis-free survival. Conclusions: Concurrent chemoradiotherapy resulted in high survival rates with an acceptable level of toxicities in patients with loco-regionally advanced nasopharyngeal carcinoma. To confirm the results of this study, well-designed randomized prospective trials are warranted.
Kong, M., Lim, Y. J., & Kim, Y. (2018). Concurrent Chemoradiotherapy for Loco-regionally Advanced Nasopharyngeal Carcinoma: Treatment Outcomes and Prognostic Factors. Asian Pacific Journal of Cancer Prevention, 19(6), 1591-1599. doi: 10.22034/APJCP.2018.19.6.1591
MLA
Moonkyoo Kong; Yu Jin Lim; Youngkyong Kim. "Concurrent Chemoradiotherapy for Loco-regionally Advanced Nasopharyngeal Carcinoma: Treatment Outcomes and Prognostic Factors". Asian Pacific Journal of Cancer Prevention, 19, 6, 2018, 1591-1599. doi: 10.22034/APJCP.2018.19.6.1591
HARVARD
Kong, M., Lim, Y. J., Kim, Y. (2018). 'Concurrent Chemoradiotherapy for Loco-regionally Advanced Nasopharyngeal Carcinoma: Treatment Outcomes and Prognostic Factors', Asian Pacific Journal of Cancer Prevention, 19(6), pp. 1591-1599. doi: 10.22034/APJCP.2018.19.6.1591
VANCOUVER
Kong, M., Lim, Y. J., Kim, Y. Concurrent Chemoradiotherapy for Loco-regionally Advanced Nasopharyngeal Carcinoma: Treatment Outcomes and Prognostic Factors. Asian Pacific Journal of Cancer Prevention, 2018; 19(6): 1591-1599. doi: 10.22034/APJCP.2018.19.6.1591
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