Background: Breast carcinomas (BCs) are sub-classified according to the molecular characteristics into luminal and non-luminal subtypes that clinically show different biological behavior, treatment and prognosis. BCs spread primarily through lymphatic vessels using cascade processes of lymphagiogenesis in which VEGF-C plays an important role during lymph node metastasis. Prognostic value of VEGF-C in luminal and non-luminal BC is still unclear and has not been studied thoroughly to clarify and define prognosis and therapeutic monitoring. Aim: To define the prognostic value of lymphangiogenesis on survival rates of luminal and non-luminal subtypes BC. Materials and Methods: This study applied prospective cohort design, using 130 patients of invasive duct carcinoma of the breast, stage I-IIIA, from Sardjito General Hospital, Indonesia and subsequent longitudinal follow-up. Immunohistochemical staining was carried out using anti-ER, -PR, -Her-2, VEGF-C, VEGFR-3 and D2-40 antibodies. The related clinicopathologic characteristics of BC patients and lymphangiogenesis determinants, including VEGF-C expression, were statistically analyzed. Results: In non-luminal BC subtypes, VEGF-C expression (HR=0.04; 95% CI=0.01-0.41), lymph node metastasis (HR=0.14; 95% CI=0.04-0.55) and stage (HR=0.30; 95% CI= 0.02-0.76) were determined as independent prognostic factors on survival rates. However, the lymphangiogenesis determinants were not associated with the survival rates of luminal BC subtypes. Conclusion: This study suggested that lymphangiogenesis affects survival rates of non-Luminal subtype rather than the luminal subtypes of BC.
Widodo, I. , Dwianingsih, E. K. , Utoro, T. , Anwar, S. L. , Aryandono, T. and ., S. (2018). Prognostic Value of Lymphangiogenesis Determinants in Luminal and Non-luminal Breast Carcinomas. Asian Pacific Journal of Cancer Prevention, 19(9), 2461-2467. doi: 10.22034/APJCP.2018.19.9.2461
MLA
Widodo, I. , , Dwianingsih, E. K. , , Utoro, T. , , Anwar, S. L. , , Aryandono, T. , and ., S. . "Prognostic Value of Lymphangiogenesis Determinants in Luminal and Non-luminal Breast Carcinomas", Asian Pacific Journal of Cancer Prevention, 19, 9, 2018, 2461-2467. doi: 10.22034/APJCP.2018.19.9.2461
HARVARD
Widodo, I., Dwianingsih, E. K., Utoro, T., Anwar, S. L., Aryandono, T., ., S. (2018). 'Prognostic Value of Lymphangiogenesis Determinants in Luminal and Non-luminal Breast Carcinomas', Asian Pacific Journal of Cancer Prevention, 19(9), pp. 2461-2467. doi: 10.22034/APJCP.2018.19.9.2461
CHICAGO
I. Widodo , E. K. Dwianingsih , T. Utoro , S. L. Anwar , T. Aryandono and S. ., "Prognostic Value of Lymphangiogenesis Determinants in Luminal and Non-luminal Breast Carcinomas," Asian Pacific Journal of Cancer Prevention, 19 9 (2018): 2461-2467, doi: 10.22034/APJCP.2018.19.9.2461
VANCOUVER
Widodo, I., Dwianingsih, E. K., Utoro, T., Anwar, S. L., Aryandono, T., ., S. Prognostic Value of Lymphangiogenesis Determinants in Luminal and Non-luminal Breast Carcinomas. Asian Pacific Journal of Cancer Prevention, 2018; 19(9): 2461-2467. doi: 10.22034/APJCP.2018.19.9.2461
)