Organogenesis and tumorigenesis seem to be following a set pretty similar instructions and pathways and tumors, like any other organ, can be seen as the summation of many different cell types. However, unlike normal tissues, intercellular networks in cancer show high degrees of robustness and plasticity, employing other cellular networks in favor of their own growth1. The integrated hallmarks of cancer were first described by Hanahan and Weinberg in 20002, and was updated in 2011 by the same scientists3. They have described 10 hallmarks including: 1) self-sufficiency in growth signals, 2) not responding to antigrowth signals, 3) unlimited proliferation, 4) resisting apoptosis, 5) genomic instability, 6) angiogenesis, 7) deregulated metabolism, 8) inflammation, 9) escaping immune destruction, and 10) tissue invasion and metastasis3, all of which have stood the test of time as being integral components of most forms of neoplasms. These unifying hallmarks are a reflection of the network structure of human cells dictating which genetic/epigenetic alterations are viable and in favor of tumor formation and progression. Among all the theories trying to explain the origins and hallmarks of cancer since Hippocrates4, clonal evolution and the stem cell hypothesis are the two theories that explain hallmarks of cancer the best5. For the purpose of this editorial our focus will be on the clonal evolution theory.
Abtahi, S., Asadipour, M., & Ghaderi, A. (2018). The Legacy of Mesenchymal Stem Cells in Vindicating the Clonal Evolution Model of Cancer. Asian Pacific Journal of Cancer Prevention, 19(8), 2029-2030. doi: 10.22034/APJCP.2018.19.8.2029
MLA
Shabnam Abtahi; Morvarid Asadipour; Abbas Ghaderi. "The Legacy of Mesenchymal Stem Cells in Vindicating the Clonal Evolution Model of Cancer". Asian Pacific Journal of Cancer Prevention, 19, 8, 2018, 2029-2030. doi: 10.22034/APJCP.2018.19.8.2029
HARVARD
Abtahi, S., Asadipour, M., Ghaderi, A. (2018). 'The Legacy of Mesenchymal Stem Cells in Vindicating the Clonal Evolution Model of Cancer', Asian Pacific Journal of Cancer Prevention, 19(8), pp. 2029-2030. doi: 10.22034/APJCP.2018.19.8.2029
VANCOUVER
Abtahi, S., Asadipour, M., Ghaderi, A. The Legacy of Mesenchymal Stem Cells in Vindicating the Clonal Evolution Model of Cancer. Asian Pacific Journal of Cancer Prevention, 2018; 19(8): 2029-2030. doi: 10.22034/APJCP.2018.19.8.2029