Age-Dependent Differential Expression of Apoptotic Markers in Rat Oral Mucosa

Document Type : Research Articles

Author

Oral Diagnostic Science Department, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.

Abstract

Objective: This study tests the hypothesis that gingival tissue produces age-dependent activation of apoptotic
markers. Methods: To address the hypothesis, a prospective experimental study was conducted on 20 adult male
albino rats, which were divided into two groups. Group 1 comprised rats aged six months (weighing 150–200 g), and
group 2 included old rats aged one year (weighing 250–300 g). Gingival tissue and buccal mucosa biopsy samples
were obtained from both groups. Histological and immunohistochemical (Bax apoptotic protein marker) sections were
analyzed for both groups. Results: Our data showed a significant decrease in the proliferative activity of oral mucosa
(gingiva and buccal mucosa) in old rats and an increase in the immunoreactivity of Bax apoptotic proteins related to
increased susceptibility of cells to apoptosis. The mucosal structures (epithelium and lamina propria) were significantly
different between the two groups. Furthermore, immunoreactivity for Bax was different between young and old rats.
Conclusions: Aging is associated with changes that lead to progressive, irreversible deterioration of the functional
capacities of several tissues and organs. Our study demonstrated the effect of age on the histological and apoptotic
behavior of oral mucosa (gingiva and buccal mucosa) cells.

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References

 
Asian Pacific Journal of Cancer Prevention
Volume 19, Issue 11
November 2018
Pages 3245-3250

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History

  • Receive Date: 06 June 2018
  • Revise Date: 31 August 2018
  • Accept Date: 07 October 2018

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