Prognostic Value of NRAS Gene for Survival of Colorectal Cancer Patients: A Systematic Review and Meta-Analysis

Document Type : Systematic Review and Meta-analysis

Authors

1 School of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou, China.

2 Spleen and Stomach Institute, Guangzhou University of Chinese Medicine, Guangzhou, China.

3 The First Affiliated Hospital,Guangzhou University of Chinese Medicine, Guangzhou, China.

4 The Third Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.

Abstract

Introduction: NRAS gene is associated with malignant proliferation and metastasis of colorectal cancer (CRC).
But its prognostic value on CRC is still unknown. The objective of this study is to perform a meta-analysis to obtain
its prognostic value on survival of CRC patients. Methods: The systematic review and meta-analysis was designed,
undertaken and reported using items from the PRISMA statement. Relevant articles were identified through PubMed
(containing Medline), Embase, Web of Science databases and Google scholar search engines from their inception up to
October 3, 2016. The articles about NRAS on prognosis of CRC patients were enrolled. The association between NRAS
and CRC survival time (including overall survival [OS], progression-free survival [PFS], and disease-free survival
[DFS]) was evaluated using hazard ratio (HR) with its corresponding 95% confidence interval (CI). Results: A total
of fifteen articles were included. High-expression of NRAS was significantly associated with poor OS (HR: 1.36, 95%
CI: 1.15–1.61), and poor PFS (HR: 1.75, 95% CI: 1.04–2.94). The combined HR of NRAS on DFS was 0.87 (95% CI:
0.37–2.03). Subgroup analysis showed that NRAS was significantly associated with poor OS for patients from Western
countries (HR: 1.38, 95% CI: 1.09–1.73), but not for those from Asian countries. Conclusions: This meta-analysis
demonstrate that NRAS gene could predict the poor prognosis for the CRC patients. More large-sample cohort studies
are needed to further confirm this conclusion.

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Main Subjects

Asian Pacific Journal of Cancer Prevention
Volume 19, Issue 11
November 2018
Pages 3001-3008

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History

  • Receive Date: 09 February 2018
  • Revise Date: 20 September 2018
  • Accept Date: 20 October 2018

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