Evaluation of Cortactin and HS1 Genes Expression: New Players in Adult B-Cell Acute Lymphoblastic leukemia

Aref, Salah; Al Agdar, Mohamed; Ramez, Ahmed; Abou Zeid, Tarek; Sabry, Mohamed; Khaled, Nada

doi:10.31557/APJCP.2021.22.3.767

Evaluation of Cortactin and HS1 Genes Expression: New Players in Adult B-Cell Acute Lymphoblastic leukemia

Document Type : Research Articles

Authors

¹ Hematology Unit, Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Egypt.

² Medical Oncology Unit, Mansoura University Oncology Center (MUOC) Mansoura University, Egypt.

³ Hematology Unit, Mansoura University Oncology Center (MUOC), Mansoura University, Egypt.

10.31557/APJCP.2021.22.3.767

Abstract

Objectives: This study aimed to assess the prognostic value of cortactin and HS1 genes expression in adult B-cell acute lymphoblastic leukemia. Methods: The study included a cohort of 74 adult B-ALL patients and 76 controls. Cortactin and HS1 genes expression were quantified by real time PCR. Results: The expression of cortactin and HS1 were significantly higher in B-ALL patients at diagnosis as compared to post induction levels (p

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