Thyroid Nodule Size as a Predictor of Malignancy in Follicular and Hurthle Neoplasms

Document Type : Research Articles


1 Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

2 Radiology Informatics Lab, Department of Radiology, Mayo Clinic, Rochester, MN, USA.

3 Department of Endocrinology, Mayo Clinic, Rochester, MN USA.


Introduction: The management of follicular (FN) and Hurthle cell neoplasms (HCN) is often difficult because of the uncertainty of malignancy risk. We aimed to assess characteristics of benign and malignant follicular and Hurthle neoplasms based on their shape and size. Materials and methods: Patients with Follicular adenoma (FA) or carcinoma (FC) and Hurthle Cell adenoma (HCA) or carcinoma (HCC) who had preoperative ultrasonography were included. Demographic data were retrieved. Size and shape of the nodules were measured. Logistic regression analyses and odds ratios were performed. Results: A total of 115 nodules with 57 carcinomas and 58 adenomas were included. Logistic regression analysis shows that the nodule height and the patient age are predictors of malignancy (p-values = 0.001 and 0.042). A cutoff value of nodule height ≥ 4 cm. produces an odds ratio of 4.5 (p-value = 0.006). An age ≥ 55 year-old demonstrates an odds ratio of 2.4-3.6 (p-value = 0.03). Taller-than-wide shape was not statistically significant (p-value = 0.613). Conclusion: FC and HCC are larger than FA and HCA in size, with a cutoff at 4 cm. Increasing age increases the odds of malignancy with a cutoff at 55 year-old. Taller-than-wide shape is not a predictor of malignancy.


Main Subjects

Volume 22, Issue 8
August 2021
Pages 2597-2602
  • Receive Date: 26 May 2021
  • Revise Date: 23 June 2021
  • Accept Date: 11 August 2021
  • First Publish Date: 11 August 2021