Introduction: Mixed phenotype acute leukemia (MPAL) is a rare heterogeneous disease with a poor prognosis. This study analyzed the clinical, immunophenotypic, molecular, and cytogenetic characteristics of a group of patients with MPAL. Methods: This prospective study included 75 patients diagnosed with MPAL according to the World Health Organization (WHO)-2016 diagnostic criteria, using cytochemistry, conventional cytogenetics, and molecular studies. Screening of BCR::ABL1 fusion gene was performed by Fluorescent in-situ hybridization (FISH) and polymerase chain reaction (PCR). Results: Children represented 49.3% of MPAL patients. The main phenotype was B-lymphoid/myeloid (80%). Molecular alterations were detected in 17 patients (22.7%). The BCR::ABL1 fusion gene was detected in 10 patients (13.3%).. Myeloid protocols were used to treat 58 patients (77.3%), and lymphatic protocols in 17. By the end of the follow-up, 57 patients (76%) achieved complete remission (CR). There was no association between BCR::ABL1 and response to treatment. The cumulative overall survival (OS) at 12 months was 47.8%. The bone marrow transplantation (BMT) was associated with better OS (p = 0.027). The disease-free survival (DFS) was not affected by all tested prognostic factors. Conclusion: MPAL is a complex entity with heterogeneous features. BCR::ABL1 is a common abnormality. BMT is associated with better OS.
Kandeel, E. Zaghloul , Hassan, N. M. and El Ashry, M. Shafik (2023). Clinical and Molecular Characteristics of Patients with Mixed Phenotype Acute Leukemia. Asian Pacific Journal of Cancer Prevention, 24(4), 1217-1223. doi: 10.31557/APJCP.2023.24.4.1217
MLA
Kandeel, E. Zaghloul, , Hassan, N. M., and El Ashry, M. Shafik. "Clinical and Molecular Characteristics of Patients with Mixed Phenotype Acute Leukemia", Asian Pacific Journal of Cancer Prevention, 24, 4, 2023, 1217-1223. doi: 10.31557/APJCP.2023.24.4.1217
HARVARD
Kandeel, E. Zaghloul, Hassan, N. M., El Ashry, M. Shafik (2023). 'Clinical and Molecular Characteristics of Patients with Mixed Phenotype Acute Leukemia', Asian Pacific Journal of Cancer Prevention, 24(4), pp. 1217-1223. doi: 10.31557/APJCP.2023.24.4.1217
CHICAGO
E. Zaghloul Kandeel , N. M. Hassan and M. Shafik El Ashry, "Clinical and Molecular Characteristics of Patients with Mixed Phenotype Acute Leukemia," Asian Pacific Journal of Cancer Prevention, 24 4 (2023): 1217-1223, doi: 10.31557/APJCP.2023.24.4.1217
VANCOUVER
Kandeel, E. Zaghloul, Hassan, N. M., El Ashry, M. Shafik Clinical and Molecular Characteristics of Patients with Mixed Phenotype Acute Leukemia. Asian Pacific Journal of Cancer Prevention, 2023; 24(4): 1217-1223. doi: 10.31557/APJCP.2023.24.4.1217
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