Antiproliferative and Apoptotic Effects of Murici (Byrsonima crassifolia (L.) Kunth and verbascifolia (L.) DC) and Taperebá (Spondias mombin L.) Extracts in Human Prostate Cell Line (PC-3)

Amaral Muxfeldt Paim, Thuane Oliveira Do; Simas, Nayara Frauches; Abreu, Joel Pimentel; Rosa, Lana; Passos  Barbosa Lima, Thuane; Teodoro, Anderson Junger

doi:10.31557/APJCP.2024.25.4.1339

Antiproliferative and Apoptotic Effects of Murici (Byrsonima crassifolia (L.) Kunth and verbascifolia (L.) DC) and Taperebá (Spondias mombin L.) Extracts in Human Prostate Cell Line (PC-3)

Document Type : Research Articles

Authors

¹ Laboratory of Functional Foods, University of State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.

² Fluminense Federal University, Food and Nutrition Department of Nutrition and Dietetics, Integrated Food and Nutrition Center (CIAN), Rio de Janeiro, Brazil.

10.31557/APJCP.2024.25.4.1339

Abstract

Objective: The present study aimed to evaluate the antiproliferative and apoptotic effects of extracts obtained from the murici (Byrsonima crassifolia (L.) Kunth and verbascifolia (L.) DC) and taperebá (Spondias mombin L.) pulps, on cell proliferation, cell cycle and apoptosis on human prostate cell line (PC-3). Methods: Four extract was produced from the pulps: murici aqueous extract (MA), taperebá aqueous extract (TA), murici ethanolic extract (ME) and taperebá ethanolic extract (TE). In the present study, the analysis of cell viability, cell cycle and apoptosis analyze were performed using the MTT method and flow cytometry. Results: The results showed that murici and taperebá extracts proved to be inhibitors of cell growth, modulation of cell cycle promoters and capable of enhancing the death in prostate carcinoma cells PC-3; suggesting a regulatory effect in prostate cell line, depending on type of extract and dosage used. Conclusion: These results open a series of perspectives on the use of these bioactive extracts in the prevention and treatment of prostate cancer.

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