Document Type : Research Articles
Authors
1
Cancer Research Center and Department of Immunology, Semnan University of Medical Sciences, Semnan, Iran.
2
Department of Medical Genetics and Molecular Biology, Faculty of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.
3
Guilan Road Trauma Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran.
4
Department of Hematology and Oncology, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
5
Department of Pharmaceutical Biotechnology, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran.
6
Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran.
7
Neuroscience Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran.
Abstract
Objective: One of the most malignant types of tumors with a remarkable ability of recurrence rate and aggressiveness is glioblastoma multiforme(GBM). Anyway, according to the restricted remedies accessible for the treatment of this serious tumor, there is no confident and stable therapeutic strategy. Notably, bioinformatics analysis can detect many effective genes in the diagnosis and treatment of GBM. Materials and Methods: Using large-scale data analysis and bioinformatics, we examined TLR2’s role in GBM. We analyzed gene expression datasets from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) to recognize disparately expressed diverse genes (DEGs) associated with TLR2. A protein-protein interaction (PPI) network was constructed to reveal potential molecular partners and functional enrichment analysis elucidated biological activities. In this account, the correlation and association between TLR2 expression and the infiltration of immune cells within the tumor microenvironment were investigated. Results: Our analysis demonstrated significant differential gene expression patterns in GBM, especially TLR2. The PPI network highlighted interactions with key proteins in pathways related to proliferation, invasion, immune evasion, and angiogenesis. Functional enrichment analysis indicated TLR2’s involvement in critical signaling processes, including toll-like receptor signaling. Interestingly, TLR2 expression was strongly associated with the infiltration of immune cells, proposing its performance and function in the tumor microenvironment. Conclusion: Understanding TLR2’s functions in glioblastoma and other cancers is vital for developing targeted therapies and immunomodulatory interventions, potentially improving clinical outcomes for patients facing these formidable diseases. Further validation and functional studies are needed to confirm TLR2’s role in cancer and expand the prospects for combination therapies.
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