EMMPRIN Correlated with β-CATENIN in Various t Stages of Colorectal Adenocarcinoma

Nugrahani, Rista Widhi; Rahniayu, Alphania; Mastutik, Gondo

doi:10.31557/APJCP.2025.26.3.1001

EMMPRIN Correlated with β-CATENIN in Various t Stages of Colorectal Adenocarcinoma

Document Type : Research Articles

Authors

¹ Department of Anatomic Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.

² Medical Staff of Anatomic Pathology Laboratory, Dr Soetomo General Academic Hospital, Surabaya, Indonesia.

10.31557/APJCP.2025.26.3.1001

Abstract

Objective: Colorectal cancer is the third malignant tumor and the second cause of death in the world. There are several prognostic factors in colorectal adenocarcinoma, one of which is the TNM stage. The T stage is determined based on the depth of tumor invasion. Various proteins can be involved in the invasion process. EMMPRIN is expressed and functions on the surface of cancerous cells. as a mediator of tumor cell invasion. Increased β-Catenin accelerates the process of tumor cell proliferation, migration, and invasion. We aimed to analyze the correlation between EMMPRIN and β-Catenin expression in the T stages of colorectal adenocarcinoma. Methods: An observational analytic study was conducted using a cross-sectional approach on 47 paraffin blocks of colorectal adenocarcinoma at the Anatomic Pathology Laboratory of Dr. Soetomo Hospital Surabaya from January 2018 to December 2022. An immunohistochemical examination was performed using EMMPRIN and β-Catenin antibodies, and then the expression of both antibodies will be analyzed using statistical tests. Result: There was a significant correlation between the expression of β-Catenin with various T stages of colorectal adenocarcinoma (p-value 0.0201). There was a significant correlation between the expression of EMMPRIN and β-Catenin in various T-stages of colorectal adenocarcinoma (p-value: 0.0209). Conclusion: There is a positive correlation between EMMPRIN and β-Catenin expression and various T-stages of colorectal adenocarcinoma with weak strength. The existence of EMMPRIN and β-Catenin stimulates colorectal cancer cells to continue invasion.

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