Health-Related Quality of Life of Non-Small Cell Lung Cancer Patients Treated with Targeted Therapy: Based on the EQ-5D-5L Scale in Vietnam

Nguyen, Chinh Van; Nguyen, Hoa Thi Thai; Luu Nguyen, Tram Nguyet; Dao, Linh Khanh; Tran Thi, Huong Thanh; Pham Huy, Kiet Tuan

doi:10.31557/APJCP.2025.26.4.1277

Health-Related Quality of Life of Non-Small Cell Lung Cancer Patients Treated with Targeted Therapy: Based on the EQ-5D-5L Scale in Vietnam

Document Type : Research Articles

Authors

¹ Department of Health Economics, Hanoi Medical University, Hanoi City, Vietnam.

² Department of Medical Oncology 2, Vietnam National Cancer Hospital, Hanoi City, Vietnam.

³ Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam.

⁴ Vietnam National Cancer Institute, Vietnam National Cancer Hospital, Department of Medical Ethics and Medical Sociology, Hanoi Medical University, Hanoi City, Vietnam.

10.31557/APJCP.2025.26.4.1277

Abstract

Objective: Non-small cell lung cancer (NSCLC) patients can prolong their life owing to targeted therapy. Assessing patients’ quality of life (QOL) can help improve QOL and prolong their lives. Methods: A cross-sectional study was conducted at the Department of Medical Oncology 1 and Medical Oncology 2, Vietnam National Cancer Hospital in Tan Trieu, Hanoi, Vietnam, from October 2022 to December 2023 on the basis of the EQ-5D-5L scale to identify the QOL of 310 patients with NSCLC who were treated with first-line targeted therapy. Nonparametric tests and Tobit regression models were used to compare the differences and identify factors related to NSCLC patients’ health-state utility. Results: Pain/discomfort (80.6%) and anxiety/depression (75.2%) were the most common dimensions, especially among NSCLC patients experiencing side effects, with only 10.0% of patients reporting no problems. The EQ-5D-5L utility and EQ-VAS scores were 0.8255 and 64.39, respectively. The presence of side effects has been shown to decrease the quality of life for patients (Coef. = -0.04203, p < 0,001). Conversely, support from health insurance has been associated with improved quality of life, with 95% support of health insurance (Coef. = 0.0594, p = 0.001) and 100% support of health insurance (Coef. = 0.0318, p = 0.013) having positive effects. Conclusion: Health insurance support and side effects related to patients’ health-state utility scores. Increasing health insurance support and improving side effects would help increase patients’ QOL.

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