Small Nucleolar RNAs in Solid Tumors: A Brief Review of the Literature on These Potential Biomarkers

Pinho, Jaqueline Diniz; Silva, Gyl Eanes Barros; Silva, Wanderley Da Costa; Matos, Ana Gabrielly De Melo; De Sousa, Larissa Rodrigues; Barbosa, Eldevan Da Silva; Prata Da Silva, Marcelli Geisse De Oliveira; Da Fonseca, Susanne Suely Santos; Teixeira Júnior, Antonio Augusto Lima; Sousa, Amanda Marques De; Teixeira De Souza, Carolina Rosal; Kayath, André Salim

doi:10.31557/APJCP.2024.25.8.2585

Small Nucleolar RNAs in Solid Tumors: A Brief Review of the Literature on These Potential Biomarkers

Document Type : Systematic Review and Meta-analysis

Authors

¹ State University of Maranhão, Zé Doca, MA, Brazil.

² Oncology Research Center, Federal University of Pará, Belém, Pará, Brazil.

³ Laboratory of Immunofluorescence and Electron Microscopy, University Hospital of the Federal University of Maranhão, Brazil.

⁴ Postgraduate Program in Adult Health, Federal University of Maranhão, São Luís, Brazil.

⁵ Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.

⁶ Federal University of Pará, Institute of Biological Sciences, Belém-PA, Brazil.

10.31557/APJCP.2024.25.8.2585

Abstract

Objective: The objective of this study was to conduct an integrative review, addressing the key findings, biological functions, and clinical significance of these biomolecules in solid tumors. Methods: This document analyzes the main data on the involvement of snoRNAs in solid tumors. For this, Pubmed and Science direct were used, with keywords. Additionally, a search for the host gene was conducted using the snoDB tool, and its chromosomal location was identified using the Hugo Gene Nomenclature Committee (HGNC). Results: According to research conducted in the literature, the majority of snoRNAs were found to be overexpressed and described as regulators of processes such as invasion, cellular proliferation, apoptosis, and migration. They are associated with clinical prognostic factors such as metastasis and worse survival. Conclusion: Therefore, it is essential to expand the investigation of snoRNAs in oncology across different types of tumors. The utilization of these biomolecules may pave the way for innovative clinical applications, such as their use in the early detection of neoplasms in non-invasive samples and as therapeutic targets. Broadening research on snoRNAs across various tumor types is crucial.

Keywords